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Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable RNA targets. As a proof of principle, in the new study the team designed a molecule that disabled the RNA causing myotonic dystrophy.The study, published online ahead of print on December 20, 2012 by the journal Angewandte Chemie, reports the creation of small molecules that recognize disease-associated RNAs, targeting them for destruction. Since small molecules are cell-permeable, the approach could ha <a href=https://www.jordann.at>jordan</a> ve benefits over traditional methods of targeting RNAs for degradation, such as antisense or RNA interference (RNAi).“We’re excited about these results,†said Matthew <a href=https://www.yeezyy.at>yeezy slide</a> Disney, an associate <a href=https://www.nbbalance.de>new balance herren</a> professor at TSRI who pioneered the research. “This approach may allow for the inactivation of many cellular RNAs by small molecules and potentially lead the way to a whole range of novel therapeutics.â€It’ Parliament, that most august of bodies at the apex of our democratic life, has been slowly fading in importance and relevance to the political life of the nation. The machinery of governance has increasingly been transferred to an extra-parliamentary set of processes that are a <a href=https://www.adidascampus.com.de>campus adidas schuhe</a> t the behest of the ruling party, do <a href=https://www.adidascampus.com.de>adidas campus beige</a> their business mostly out of the public eye, and have little by way of transparency or accountability. Robust parliamentary debate within a House filled with all parties’ elected representatives is a thing of the past, ancient history, and the House is rarely full. To be sure the peripheral functions of the House in the form of parliamentary committees continue and are generally accepted to be mostly hard working, but the public playing out of the political drama now happens behind the arras.The joint session of parliament on October 5 was called by the prime minister and is a welcome return to best <a href=https://www.stanley-cup.com.de>stanley kaufen</a> custom and practice. The national security of the state has come under sustain
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„N„€„r„„u „„‚„p„r„y„|„p „„€„{„…„„{„y „y „t„€„ƒ„„„p„r„{„y „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „…„w„u „t„u„z„ƒ„„„r„…„„„? „K„‚„…„s„|„€„ƒ„…„„„€„‰„~„p„‘ „„€„{„…„„{„p „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „„„€„|„Ž„{„€ „~„p „€„†„y„ˆ„y„p„|„Ž„~„€„} „ƒ„p„z„„„u „„€ „ƒ„ƒ„„|„{„u, „q„€„|„Ž„Š„u „~„y„s„t„u?
„K„‚„y„ƒ„„„p„|„|„ „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „…„w„u „ƒ„‚„p„r„~„y„r„p„„„ „ƒ „s„‚„p„t„€„}? „Y„„{„p„‚„~„€„u „{„p„‰„u„ƒ„„„r„€ „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „~„y„{„€„s„t„p „~„y„{„€„s„€ „~„u „€„ƒ„„„p„r„y„„ „‚„p„r„~„€„t„…„Š„~„„} „y„|„y „q„u„x„‚„p„x„|„y„‰„~„?
„M„€„}„u„~„„„p„|„Ž„~„p„‘ „„€„{„…„„{„p „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „y „{„‚„…„s„|„€„ƒ„…„„„€„‰„~„p„‘ „„€„„„t„u„‚„w„{„p „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „r„ƒ„u„s„t„p „~„p „ƒ„r„‘„x„y, „t„p„w„u „r „r„„‡„€„t„~„„u „y „„‚„p„x„t„~„y„‰„~„„u „t„~„y?
„Z„u„t„‚„€„ƒ„„„Ž „~„p„ƒ„„„y „r „x„p„{„|„p„t„{„p„‡ „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „y„~„€„s„t„p „t„p„w„u „…„t„y„r„|„‘„u„„, „„€„„„€„}„… „‰„„„€ „x„p„{„|„p„t„{„y „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „r„ƒ„u„s„t„p „~„p 10% „q„€„|„Ž„Š„u „‰„u„} „r „x„p„{„p„x„u?
„H„p„~„‘„„„Ž „t„u„~„Ž„s„y „y„|„y „x„p„~„‘„„„Ž „t„€„‚„€„w„{„… „„„p„{„€„s„€ „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „„„„€ „~„u „ƒ„„„„t„~„€, „„„„€ „w„y„x„~„Ž „{„€„„„€„‚„€„z „w„y„r„…„„ „„€„ƒ„„„€„‘„~„~„€ „|„„t„y „r „M„€„ƒ„{„r„u?
„V„€„‚„€„Š„€ „‰„„„€ „B„ „r„ƒ„u„s„t„p „~„p „ƒ„r„‘„x„y - „ƒ„p„}„„z „‰„p„ƒ„„„„z „€„„„x„„r „„‚„€ „~„p„Š „K„€„{„p„y„~ („K„O„K„R) „r „M„€„ƒ„{„r„u „x„p „„€„ƒ„|„u„t„~„y„u „„‘„„„Ž „|„u„„ „‚„p„q„€„„„ „~„p „‚„„~„{„u „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u!
„U„y„~„p„|„Ž„~„p„‘ „r„u„‚„ƒ„y„‘ „‚„p„x„‚„p„q„€„„„€„{ „r„ƒ„u„‡ „‚„u„ˆ„u„„„„€„r „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u „}„€„w„~„€ „{„…„„y„„„Ž „~„p „~„p„Š„u„} „ƒ„p„z„„„u „…„w„u „~„u „„u„‚„r„„z „s„€„t? „T„|„u„„„u„„„Ž „r „N„u„q„u„ƒ„p „ƒ„{„r„€„x„Ž „r„ƒ„u „„‚„u„s„‚„p„t„ „}„€„w„~„€ „„„€„|„Ž„{„€ „ƒ „~„p„Š„y„} „K„€„{„p„y„~ („K„O„K„R) „€„} „r „M„€„ƒ„{„r„u!
„E„t„y„~„ƒ„„„r„u„~„~„„z „M„p„s„p„x„y„~ „r „M„€„ƒ„{„r„u „{„€„„„€„‚„„z „‚„u„p„|„Ž„~„€ „q„u„x„€„„p„ƒ„~„€ „t„€„ƒ„„„p„r„|„‘„u„„ „„„€„r„p„‚ „r „‚„…„{„y „~„u „r„p„w„~„€ „{„p„{„€„s„€ „{„€„|„y„‰„u„ƒ„„„r„p, „^„„„€ „y„}„u„~„~„€ „~„p„Š „R„p„z„„ „K„€„{„p„y„~ („K„O„K„R) „p „r „M„€„ƒ„{„r„u! „N„p„Š „K„€„{„p„y„~ („K„O„K„R) „r „M„€„ƒ„{„r„u „x„~„p„ „B„ƒ„u!
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„M„O„R„K„B„@-„Q„O„R„R„I„`-„K„€„{„p„y„~ („K„O„K„R) -„H„@„K„L„@„D„K„I-„D„O„R„S„@„B„K„@ „B „Q„T„K„I -„C„@„Q„@„N„S„I„I - „K„T„P„I„S„] - „K„Q„T„C„L„O„R„T„S„O„X„N„O -„L„_„A„O„J „Q„@„J„O„N - „P„O„D„M„O„R„K„O„B„]„E „S„O„G„E „E„R„S„] - „Q„O„R„R„I„`
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Swml Prediction of Gastric Cancer Metastasis through Urinary Metabolomic Investigation using GC/MS
“We must not only look inside the tumour but also outside of it,†saysHéctor Peinado, a researcher at the Spanish National Cancer Research Centre (CNIO). How tumours manipulate their environment to advance is one of the big questions that Peinado has been trying to answer for years. For decades “to fight tumours, researchers focused on studying their intrinsic behaviour, but not on their surroundings.â€Peinado is the head of the CNIO <a href=https://www.adidas-yeezys.fr>adidas yeezys</a> 'sMicroenvironment & Metastasis Group, which s <a href=https://www.asicsgel.de>asics outlets</a> tudies the mechanisms involved in metastatic progression, including how nanop <a href=https://www.nbbalance.de>new balances 530</a> articles called exosomes, which are released by tumours, manipulate the tumour microenvironment to favour metastasis. A paper published this week in the prestigious journalNature Cancerdescribes how this critical process for melanoma progression occurs: exosomes travel and home to the sentinel lymph node -the lymph node where metastasis initially occurs- from where they remotely prepare a favourable environment -the pre-metastatic ni KARACHI:On first glimpse, the still life paintings by artist Aamir Ahmed Qureshi could easily be mistaken for photographs.The detail with which each stroke has been applied makes his work, being showcased at Citi Art Gallery, <a href=https://www.adidas-samba-adidas.it>adidas samba nera</a> realistic and flawless. The work captures the spirit of the artist's everyday life and what is present around him.Qureshi is a Karachi-based artist who studied at Institute of Arts and Craft at Arts Council. Being associated with the profession of advertising, for Qureshi, painting is a hobby that he often indulges after being done with the day's work.Cultural trip: <a href=https://www.campusadidas.it>campus adidas beige</a> Artist Natasha Jozi on experimenting with workIn this particular exhibition, he has focused on showcasing his drawing and painting skills and both have been worked upon with great sensitivity. It seems as if Qureshi imagined himself being present in the surroundings he has painted and made the objects his centre of attention; be it a <a href=https://www.adidascampus.com.de>adidas schuhe campus</a> table with a pot and lantern or a window or a door in a veranda.A whi
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Agilent Technologies Inc. has announced that its acquisition of cancer diagnostics company Dako has been completed.Agilent, which paid $2.2 billion in cash for Dako (on a debt-free basis), expects the acquisition to help strengthen Agilen <a href=https://www.adidas-yeezys.fr>yeezy 350</a> t's position in life sciences, with a focus on product development to help in the fight against cancer.Bill Sullivan, Agilent president and CEO, said, "The acquisition of Dako, the largest in Agilent's history, is another step in the expansion of our life science business. Th <a href=https://www.adidas-yeezy.de>yeezy 700</a> e addition of Dako and its portfolio will help Agilent accelerate our growth in several rapidly expanding areas of diagnostics, as well as strengthen our existing offerings. I look forward to the exciting possibilities ahead.""Agilent and Dako have some of the best talent and technolog <a href=https://www.nike-dunk.it>nike dunk donna</a> y in the world," said Lars Holmkvist, Dako CEO.Holmkvist continued, "By combining resources, we believe that both of our companies will benefit, as will our customers and employees. I have great confi LAHORE:Information Technology University (ITU) Vice Chancellor Umar Saif and the American embassy’s Deputy Chief of Mission Jonathan Pratt sig <a href=https://www.adidassamba.com.de>adidas samba adidas</a> ned a Memorandum of Understanding (MoU) on Tue <a href=https://www.campusadidas.it>adidas original campus</a> sday to establish a Lincoln Corner at the varsity.“Lincoln Corners present a great opportunity to build bridges and increase mutual understanding between Pakistan and the United States,†Saif said. The corners are partnerships between diplomatic outposts of the United States and selected institutions in Pakistan. Located across universities, public libraries, and other institutions, Lincoln Corners further information about the United States, English language learning, Education USA, cultural programmes and alumni activities.“The Lahore Lincoln Corn <a href=https://www.stanleycups.fr>stanley cups</a> er will host academic programmes, speakers from the United States, English language activities and cultural events like the Ari Roland Jazz Quartet’s recent performance at the ITU,†Pratt said. He said such spaces facilitated dialogue, countered negative pr
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Fvuh We have overcome heartless enemy, says army chief
Pakistan Tehreek-e-Insaf (PTI) chairman Imran Khan has said people in Pakistan will celebrate and distribute sweets if the military takes over, unlike what happened in Turkey.“People will celebrate the milit <a href=https://www.adidassamba.com.de>adidas samba og</a> ary take over in Pakistan. The democracy here is threatened by Nawaz Sharif’s monarchy, not military,†he said while addressing at political demonstration in Islam Garh, Azad Kashmir ahead of elections in the valley on July 21.Imran said the Turkish masses took to the roads and streets against the attempted coup because their president served his people.Govt failed to address Kashmir issue owing to Nawaz-Modi friendship: Bilawalبھیک مانگنے اورقرضے والوں Ú©ÛŒ کوئی Ù‚ <a href=https://www.valela.at>uggs</a> در Ù†Ûیں کرتا، عمران خان#KashmirKaptaanKa pic.twitter.com/cWevS3rpCo <a href=https://www.stanley-cup.com.de>stanleycup</a> — PTI (@PTIofficial) July 17, 2016“Erdogan served his people, paid off their country’s debts, and constructed hospitals. That is why people supported him against the military.â€He lambasted PM Nawaz for ‘keeping mum’ over the Panamagate controversy.“We d MIT engineers have designed a new nanoparticle sensor that could enable early diagnosis of cancer with a simple urine test. The sensors, which can detect many different cancerous proteins, could also be used to distinguish the type of a tumor or how it is responding to treatment.The nanoparticles are designed s <a href=https://www.adidas-yeezys.fr>baskets yeezy</a> o that when they encounter a tumor, they shed short sequence <a href=https://www.adidas-yeezys.fr>yeezy slides</a> s of DNA that are excreted in the urine. Analyzing these DNA “barcodes†can reveal distinguishing features of a particular patient’s tumor. The researchers designed their test so t <a href=https://www.nike-dunks.de>nike high dunk</a> hat it can be performed using a strip of paper, similar to an at-home Covid test, which they hope could make it affordable and accessible to as many patients as possible.Want more breaking news?Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.Subscribe for FREE
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Ptmj Intestinal Cells Successfully Generated From Human Induced Pluripotent Stem Cells
On Wednesday, we covered the overreaction by a few important online sources to an International Journal of Biological Sciences article claiming to find “signs of toxicity†in three varieties of genetically modified (GM) corn produced by Monsanto. We <a href=https://www.asicsgel.de>asics gelkayano</a> posted some caveats that made us uneasy about the study, such as the funding sources, the unknown quality of the journal, and the fact that the toxicity claims rely on reinterpreting statistical data that Gilles-Eric Séralini and his coauthors themselves note is not as robust as it needs to be.Karl Haro von Mogel, a University of Wisconsin Ph.D. student who works with Pamela Ronald (the GM expert we quoted <a href=https://www.asicsgel.de>asics gel</a> in our last post), responded with some other problems he has on this study. He has a blog post of his own (in which he gets hopping mad at coverage that attributed organ damage, organ failure, or even cancer to the rats in the study). But here are the major issues he points out to DISCOVER:1. Cherry-picking. “They were <a href=https://www.nike-dunk.it>dunk panda</a> picking out about 2 LAHORE:Real estate markets of Pakistan are likely <a href=https://www.stanley-cup.us>stanley brand</a> to resume business in full swing this week after remaining somewhat stagnant for about a month as market players are confident they will be able to get maximum relief from Finance Minister Ishaq Dar in a meeting slated for Monday.At present, real estate agents of Lahore and Karachi – two big markets of the country – are protesting <a href=https://www.adidas-samba-adidas.es>adidas samba negras</a> against the increase in taxes and revision in the land evaluation mechanism in the 2016-17 budget announced in early June.Govt may double tax on transfer of propertiesHowever, some players believe that the government will take back the deci <a href=https://www.nbbalance.it>new balance nere</a> sions, which will spur activities in property markets across the country.“We hope the government withdraws most of the decisions taken in the recent budget,†said Mian Talat, a leader of realtors in Lahore.He was of the view that the government would continue collecting taxes on the value of land set by the provincial revenue departments with some upward revision in the pric